Enhanced neuroinvasion by smaller, soluble prions

Enhanced neuroinvasion by smaller, soluble prions

Abstract Infectious prion aggregates can propagate from extraneural sites into the brain with remarkable efficiency, likely transported via peripheral nerves. Yet not all prions spread into the brain, and the physical properties of a prion that is capable of transit within neurons remain unclear. We...

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Bibliographic Details
Main Authors: Cyrus Bett, Jessica Lawrence, Timothy D. Kurt, Christina Orru, Patricia Aguilar-Calvo, Anthony E. Kincaid, Witold K. Surewicz, Byron Caughey, Chengbiao Wu, Christina J. Sigurdson
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Acta Neuropathologica Communications
Subjects:
Prion disease
Amyloid
Fibrils
Neurodegeneration
Prion strains
Axonal transport
Online Access:http://link.springer.com/article/10.1186/s40478-017-0430-z

Internet

http://link.springer.com/article/10.1186/s40478-017-0430-z

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