Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins

The increasing need for site-specific protein decorations that mimic natural posttranslational modifications requires access to a variety of noncanonical amino acids with moieties enabling bioorthogonal conjugation chemistry. Here we present the incorporation of long-chain olefinic amino acids into...

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Bibliographic Details
Main Authors: Matthias P. Exner, Sebastian Köhling, Julie Rivollier, Sandrine Gosling, Puneet Srivastava, Zheni I. Palyancheva, Piet Herdewijn, Marie-Pierre Heck, Jörg Rademann, Nediljko Budisa
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Molecules
Subjects:
stop codon suppression
protein decoration
noncanonical amino acid
pyrrolysyl-tRNA synthetase
thiol-ene coupling
metathesis
Online Access:http://www.mdpi.com/1420-3049/21/3/287

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http://www.mdpi.com/1420-3049/21/3/287

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