Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform

Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform

Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification and classification of HLA genes to assist with precision medicine efforts in disease and transplantation, the efficiency of these methods are impeded by the absence of adequately-characterized high-f...

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Bibliographic Details
Main Authors: Shingo Suzuki, Swati Ranade, Ken Osaki, Sayaka Ito, Atsuko Shigenari, Yuko Ohnuki, Akira Oka, Anri Masuya, John Harting, Primo Baybayan, Miwako Kitazume, Junichi Sunaga, Satoko Morishima, Yasuo Morishima, Hidetoshi Inoko, Jerzy K. Kulski, Takashi Shiina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
human leukocyte antigen
HLA
next-generation sequencing
NGS
SMRT sequencing
genotyping
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02294/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02294/full

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