Graphical approach to model reduction for nonlinear biochemical networks.

Model reduction is a central challenge to the development and analysis of multiscale physiology models. Advances in model reduction are needed not only for computational feasibility but also for obtaining conceptual insights from complex systems. Here, we introduce an intuitive graphical approach to...

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Bibliographic Details
Main Authors: David O Holland, Nicholas C Krainak, Jeffrey J Saucerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3162006?pdf=render