3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

3,3'-Diindolylmethane (DIM), one of the active products derived from Brassica plants, is a promising antitumor agent. The present study indicated that DIM significantly induced apoptosis in U937 human leukemia cells in dose- and time-dependent manners. These events were also noted in other huma...

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Bibliographic Details
Main Authors: Ning Gao, Senping Cheng, Amit Budhraja, E-Hu Liu, Jieping Chen, Deying Chen, Zailin Yang, Jia Luo, Xianglin Shi, Zhuo Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363731/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363731/pdf/?tool=EBI

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