Methods and approaches in the topology-based analysis of biological pathways

Methods and approaches in the topology-based analysis of biological pathways

The goal of pathway analysis is to identify the pathways significantly impacted in a given phenotype. Many current methods are based on algorithms which consider pathways as simple gene lists, dramatically under-utilizing the knowledge that such pathways are meant to capture. During the past few y...

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Bibliographic Details
Main Authors: Cristina eMitrea, Zeinab eTaghavi, Behzad eBokanizad, Samer eHanoudi, Rebecca eTagett, Michele eDonato, Calin eVoichita, Sorin eDraghici
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Physiology
Subjects:
mathematical model
topology
pathway analysis
Signaling Pathways
Metabolic pathways
network topology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00278/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00278/full

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