p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice

p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice

Muscle wasting is the key manifestation of cancer-associated cachexia, a lethal metabolic disorder seen in over 50% of cancer patients. Autophagy is activated in cachectic muscle of cancer hosts along with the ubiquitin-proteasome pathway (UPP), contributing to accelerated protein degradation and mu...

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Bibliographic Details
Main Authors: Zhelong Liu, Ka Wai Thomas Sin, Hui Ding, HoangAnh Amy Doan, Song Gao, Hongyu Miao, Yahui Wei, Yiman Wang, Guohua Zhang, Yi-Ping Li
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-10-01
Series:Cell Stress
Subjects:
cachexia
muscle wasting
C/EBPβ
LC3b
Gabarapl1
ULK1
Online Access:http://www.cell-stress.com/researcharticles/p38%CE%B2-mapk-mediates-ulk1-dependent-induction-of-autophagy-in-skeletal-muscle-of-tumor-bearing-mice/

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http://www.cell-stress.com/researcharticles/p38%CE%B2-mapk-mediates-ulk1-dependent-induction-of-autophagy-in-skeletal-muscle-of-tumor-bearing-mice/

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