Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair mechanisms that modulate this process and gover...

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Bibliographic Details
Main Authors: Gantsetseg Tumurkhuu, Shuang Chen, Erica N. Montano, Duygu Ercan Laguna, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Timothy R. Crother, Mariko Ishimori, Daniel J. Wallace, Caroline A. Jefferies, Moshe Arditi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
SLE
Ogg1
8-OH-dG
cGAS-STING pathway
IFN-stimulated genes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.554725/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.554725/full

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