Comparison of somatic variant detection algorithms using Ion Torrent targeted deep sequencing data

Comparison of somatic variant detection algorithms using Ion Torrent targeted deep sequencing data

Abstract Background The application of next-generation sequencing in cancer has revealed the genomic landscape of many tumour types and is nowadays routinely used in research and clinical settings. Multiple algorithms have been developed to detect somatic variation from sequencing data using either...

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Bibliographic Details
Main Authors: Qing Wang, Vassiliki Kotoula, Pei-Chen Hsu, Kyriaki Papadopoulou, Joshua W. K. Ho, George Fountzilas, Eleni Giannoulatou
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Medical Genomics
Subjects:
Cancer genome
Ion torrent deep sequencing
Somatic variant calling
Methods evaluation
Read depth
Mutational signature
Online Access:https://doi.org/10.1186/s12920-019-0636-y

Internet

https://doi.org/10.1186/s12920-019-0636-y

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