Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus

Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus

Secondary metabolite (SM) production in filamentous fungi is mechanistically associated with chromatin remodeling of specific SM clusters. One locus recently shown to be involved in SM suppression in Aspergillus nidulans was CclA, a member of the histone 3 lysine 4 methylating COMPASS complex. Here...

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Bibliographic Details
Main Authors: Jonathan M. Palmer, Jin Woo Bok, Seul Lee, Taylor R.T. Dagenais, David R. Andes, Dimitrios P. Kontoyiannis, Nancy P. Keller
Format: Article
Language:English
Published: PeerJ Inc. 2013-02-01
Series:PeerJ
Subjects:
COMPASS complex
Gliotoxin
Histone methylation
Secondary metabolism
Growth and development
6-azauracil sensitivity
Online Access:https://peerj.com/articles/4.pdf

Internet

https://peerj.com/articles/4.pdf

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