Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin

Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin

Heparin or highly sulfated heparan sulfate (HS) has been described in different invertebrates. In ascidians (Chordata-Tunicata), these glycosaminoglycans occur in intracellular granules of oocyte accessory cells and circulating basophil-like cells, resembling mammalian mast cells and basophils, resp...

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Bibliographic Details
Main Authors: Wallace S. Abreu, Paulo A. G. Soares, Juliana M. Motta, Eliene O. Kozlowski, Felipe C. O. B. Teixeira, Mariana A. Soares, Lubor Borsig, Paulo A. S. Mourão, Mauro S. G. Pavão
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Marine Drugs
Subjects:
heparan sulfate
cancer
coagulation
ascidian glycosaminoglycans
P-selectin
marine biology
nuclear magnetic resonance
Online Access:https://www.mdpi.com/1660-3397/17/6/351

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https://www.mdpi.com/1660-3397/17/6/351

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