Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer’s disease

Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is the most common dementia worldwide and is characterized by the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of hyperphosphorylated Tau protein. These changes lead to progressive neuronal degeneration and dysfunction, resulting in severe brai...

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Bibliographic Details
Main Authors: Michele Longoni Calió, Amanda Cristina Mosini, Darci Souza Marinho, Geisa Nogueira Salles, Fernando Henrique Massinhani, Gui Mi Ko, Marimélia Aparecida Porcionatto
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Alzheimer’s disease
amyloid-beta
leptin
neurogenesis
neural stem cells
hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304940

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http://www.sciencedirect.com/science/article/pii/S0969996120304940

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