Phosphonate coating of SiO2 nanoparticles abrogates inflammatory effects and local changes of the lipid composition in the rat lung: a complementary bioimaging study

Phosphonate coating of SiO2 nanoparticles abrogates inflammatory effects and local changes of the lipid composition in the rat lung: a complementary bioimaging study

Abstract Background The well-known inflammatory and fibrogenic changes of the lung upon crystalline silica are accompanied by early changes of the phospholipid composition (PLC) as detected in broncho-alveolar lavage fluid (BALF). Amorphous silica nanoparticles (NPs) evoke transient lung inflammatio...

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Bibliographic Details
Main Authors: Mandy Großgarten, Matthias Holzlechner, Antje Vennemann, Anna Balbekova, Karin Wieland, Michael Sperling, Bernhard Lendl, Martina Marchetti-Deschmann, Uwe Karst, Martin Wiemann
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Particle and Fibre Toxicology
Subjects:
Lung surfactant
Silica nanoparticles
In vitro and in vivo lung toxicity
MALDI-MS imaging
Phospholipids
Phosphonate coating
Online Access:http://link.springer.com/article/10.1186/s12989-018-0267-z

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http://link.springer.com/article/10.1186/s12989-018-0267-z

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