Development of Second-Tier Liquid Chromatography-Tandem Mass Spectrometry Analysis for Expanded Newborn Screening in Japan

Development of Second-Tier Liquid Chromatography-Tandem Mass Spectrometry Analysis for Expanded Newborn Screening in Japan

To minimize false-positive cases in newborn screening by tandem mass spectrometry in Japan, practical second-tier liquid chromatography-tandem mass spectrometry analyses have been developed using a multimode ODS column with a single set of mobile phases and different gradient elution programs specif...

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Bibliographic Details
Main Authors: Yosuke Shigematsu, Miori Yuasa, Nobuyuki Ishige, Hideki Nakajima, Go Tajima
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Neonatal Screening
Subjects:
isomer
stable-isotope dilution
derivatization
homocystinuria
cobalamin
biotin
Online Access:https://www.mdpi.com/2409-515X/7/3/44

Internet

https://www.mdpi.com/2409-515X/7/3/44

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