Molecular Basis for Ser/Thr Specificity in PKA Signaling

Molecular Basis for Ser/Thr Specificity in PKA Signaling

cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this substrate specificity. We employ classical en...

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Bibliographic Details
Main Authors: Matthias J. Knape, Maximilian Wallbott, Nicole C.G. Burghardt, Daniela Bertinetti, Jan Hornung, Sven H. Schmidt, Robin Lorenz, Friedrich W. Herberg
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
cAMP-dependent protein kinase
PKA
cAMP signaling
protein kinases
kinase function
phosphorylation
Online Access:https://www.mdpi.com/2073-4409/9/6/1548

Internet

https://www.mdpi.com/2073-4409/9/6/1548

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