Molecular Basis for Ser/Thr Specificity in PKA Signaling
cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this substrate specificity. We employ classical en...
Main Authors: | Matthias J. Knape, Maximilian Wallbott, Nicole C.G. Burghardt, Daniela Bertinetti, Jan Hornung, Sven H. Schmidt, Robin Lorenz, Friedrich W. Herberg |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/6/1548 |
Similar Items
-
Crosstalk between the cAMP-PKA pathway and the β-1,6-endoglucanase in Verticillium dahliae
by: Lugard EBOIGBE, et al.
Published: (2020-01-01) -
Non-Covalent Selection Methodologies Utilizing Phage Display
by: Meyer, Scott C.
Published: (2007) -
Studies of the Mechanism of the Catalytic Subunit of cAMP Dependent Protein Kinase
by: Yoon, Moon-Young
Published: (1989) -
Protein Kinase A Catalytic and Regulatory Subunits Interact Differently in Various Areas of Mouse Brain
by: Carla Mucignat-Caretta, et al.
Published: (2020-04-01) -
Protein Kinase A Distribution Differentiates Human Glioblastoma from Brain Tissue
by: Carla Mucignat-Caretta, et al.
Published: (2017-12-01)