Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts

Abstract Periodontitis is an inflammatory disease associated with severe alveolar bone loss and is dominantly induced by lipopolysaccharide from Gram-negative bacteria; however, the role of Gram-positive bacteria in periodontal bone resorption remains unclear. In this study, we examined the effects...

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Bibliographic Details
Main Authors: Tsukasa Tominari, Ayumi Sanada, Ryota Ichimaru, Chiho Matsumoto, Michiko Hirata, Yoshifumi Itoh, Yukihiro Numabe, Chisato Miyaura, Masaki Inada
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92744-5