Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-02938-1 |
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doaj-8069efa147334bedbe33b1e19b4d72412021-05-11T10:11:23ZengNature Publishing GroupNature Communications2041-17232018-02-019111410.1038/s41467-018-02938-1Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinasePraveena S. Thiagarajan0Maksim Sinyuk1Soumya M. Turaga2Erin E. Mulkearns-Hubert3James S. Hale4Vinay Rao5Abeba Demelash6Caner Saygin7Arnab China8Tyler J. Alban9Masahiro Hitomi10Luke A. Torre-Healy11Alvaro G. Alvarado12Awad Jarrar13Andrew Wiechert14Valery Adorno-Cruz15Paul L. Fox16Benjamin C. Calhoun17Jun-Lin Guan18Huiping Liu19Ofer Reizes20Justin D. Lathia21Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicCase Comprehensive Cancer CenterDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Pathology, Cleveland ClinicDepartment of Cancer Biology, University of CincinnatiCase Comprehensive Cancer CenterDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicConnexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.https://doi.org/10.1038/s41467-018-02938-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Praveena S. Thiagarajan Maksim Sinyuk Soumya M. Turaga Erin E. Mulkearns-Hubert James S. Hale Vinay Rao Abeba Demelash Caner Saygin Arnab China Tyler J. Alban Masahiro Hitomi Luke A. Torre-Healy Alvaro G. Alvarado Awad Jarrar Andrew Wiechert Valery Adorno-Cruz Paul L. Fox Benjamin C. Calhoun Jun-Lin Guan Huiping Liu Ofer Reizes Justin D. Lathia |
| spellingShingle |
Praveena S. Thiagarajan Maksim Sinyuk Soumya M. Turaga Erin E. Mulkearns-Hubert James S. Hale Vinay Rao Abeba Demelash Caner Saygin Arnab China Tyler J. Alban Masahiro Hitomi Luke A. Torre-Healy Alvaro G. Alvarado Awad Jarrar Andrew Wiechert Valery Adorno-Cruz Paul L. Fox Benjamin C. Calhoun Jun-Lin Guan Huiping Liu Ofer Reizes Justin D. Lathia Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase Nature Communications |
| author_facet |
Praveena S. Thiagarajan Maksim Sinyuk Soumya M. Turaga Erin E. Mulkearns-Hubert James S. Hale Vinay Rao Abeba Demelash Caner Saygin Arnab China Tyler J. Alban Masahiro Hitomi Luke A. Torre-Healy Alvaro G. Alvarado Awad Jarrar Andrew Wiechert Valery Adorno-Cruz Paul L. Fox Benjamin C. Calhoun Jun-Lin Guan Huiping Liu Ofer Reizes Justin D. Lathia |
| author_sort |
Praveena S. Thiagarajan |
| title |
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase |
| title_short |
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase |
| title_full |
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase |
| title_fullStr |
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase |
| title_full_unstemmed |
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase |
| title_sort |
cx26 drives self-renewal in triple-negative breast cancer via interaction with nanog and focal adhesion kinase |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-02-01 |
| description |
Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG. |
| url |
https://doi.org/10.1038/s41467-018-02938-1 |
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