Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion

Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion

Abstract Background Both defective DNA methylation and active DNA demethylation processes are emerging as important risk factors in chronic lymphocytic leukemia (CLL). However, associations between 5-cytosine epigenetic markers and the most frequent chromosomal abnormalities detected in CLL remain t...

Full description

Bibliographic Details
Main Authors: Cristina Bagacean, Christelle Le Dantec, Christian Berthou, Adrian Tempescul, Hussam Saad, Anne Bordron, Mihnea Zdrenghea, Victor Cristea, Nathalie Douet-Guilbert, Yves Renaudineau
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Clinical Epigenetics
Subjects:
Chronic lymphocytic leukemia
Cytogenetics
DNA methylation
Active DNA demethylation
DNMT
TET
Online Access:http://link.springer.com/article/10.1186/s13148-017-0422-7

Internet

http://link.springer.com/article/10.1186/s13148-017-0422-7

Similar Items