Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients

Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients

Introduction: Dasatinib is a dual SRC/ABL tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) that is known to have unique immunomodulatory effects. In particular, dasatinib intake typically causes lymphocytosis, which has been linked to better clinical response. Since the underly...

Full description

Bibliographic Details
Main Authors: Beatriz Colom-Fernández, Anna Kreutzman, Ana Marcos-Jiménez, Valentín García-Gutiérrez, Carlos Cuesta-Mateos, Itxaso Portero-Sainz, Yaiza Pérez-García, Luis Felipe Casado, Fermín Sánchez-Guijo, Joaquín Martínez-López, Rosa M. Ayala, Concha Boqué, Blanca Xicoy, Isabel Montero, César Soto, Raquel Paz, Gabriela Silva, Lorena Vega-Piris, Juan Luis Steegmann, Cecilia Muñoz-Calleja
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
Dasatinib
lymphocytosis
CCR7
migration
chronic myeloid leukemia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01340/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01340/full

Similar Items