Imputing single-cell RNA-seq data by combining graph convolution and autoencoder neural networks

Summary: Single-cell RNA sequencing technology promotes the profiling of single-cell transcriptomes at an unprecedented throughput and resolution. However, in scRNA-seq studies, only a low amount of sequenced mRNA in each cell leads to missing detection for a portion of mRNA molecules, i.e. the drop...

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Bibliographic Details
Main Authors: Jiahua Rao, Xiang Zhou, Yutong Lu, Huiying Zhao, Yuedong Yang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003618