Promiscuous activities of heterologous enzymes lead to unintended metabolic rerouting in Saccharomyces cerevisiae engineered to assimilate various sugars from renewable biomass

Promiscuous activities of heterologous enzymes lead to unintended metabolic rerouting in Saccharomyces cerevisiae engineered to assimilate various sugars from renewable biomass

Abstract Background Understanding the global metabolic network, significantly perturbed upon promiscuous activities of foreign enzymes and different carbon sources, is crucial for systematic optimization of metabolic engineering of yeast Saccharomyces cerevisiae. Here, we studied the effects of prom...

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Bibliographic Details
Main Authors: Eun Ju Yun, Eun Joong Oh, Jing-Jing Liu, Sora Yu, Dong Hyun Kim, Suryang Kwak, Kyoung Heon Kim, Yong-Su Jin
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Biotechnology for Biofuels
Subjects:
Metabolite profiling
Saccharomyces cerevisiae
Renewable biomass
Carbon source
Promiscuous activity
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13068-018-1135-7

Internet

http://link.springer.com/article/10.1186/s13068-018-1135-7

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