Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer

Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer

Resistance to androgen-receptor (AR) directed therapies is, among other factors, associated with Myc transcription factors that are involved in development and progression of many cancers. Overexpression of N-Myc protein in prostate cancer (PCa) leads to its transformation to advanced neuroendocrine...

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Bibliographic Details
Main Authors: Anh-Tien Ton, Kriti Singh, Hélène Morin, Fuqiang Ban, Eric Leblanc, Joseph Lee, Nada Lallous, Artem Cherkasov
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
Myc
aurora a kinase
drug discovery
dual inhibitor
polypharmacology
Online Access:https://www.mdpi.com/1422-0067/21/21/8277

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https://www.mdpi.com/1422-0067/21/21/8277

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