Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells

Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells

Multidrug resistance (MDR) is one of conventional cancer chemotherapy’s limitations. Our group previously synthesized a series of quinoline-based compounds in an attempt to identify novel anticancer agents. With a molecular docking analysis, the novel compound 160a was predicted to target...

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Bibliographic Details
Main Authors: Yuanyuan Zhou, Po-yee Chung, Jessica Yuen-wuen Ma, Alfred King-yin Lam, Simon Law, Kwok-wah Chan, Albert Sun-chi Chan, Xingshu Li, Kim-hung Lam, Chung-hin Chui, Johnny Cheuk-on Tang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biology
Subjects:
anticancer
multidrug resistance
p-glycoprotein
quinoline compounds
Online Access:https://www.mdpi.com/2079-7737/8/4/75

Internet

https://www.mdpi.com/2079-7737/8/4/75

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