Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

Abstract Cellular injury in AQP4-IgG seropositive neuromyelitis spectrum disorder (herein called NMO) involves AQP4-IgG binding to astrocytes, resulting in astrocyte injury by complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) mechanisms. The rapid disease pr...

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Bibliographic Details
Main Authors: Tianjiao Duan, Alex J. Smith, Alan S. Verkman
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Acta Neuropathologica Communications
Subjects:
NMO
Aquaporin-4
ADCC
Leukocyte
Astrocyte
Online Access:http://link.springer.com/article/10.1186/s40478-019-0766-7

Internet

http://link.springer.com/article/10.1186/s40478-019-0766-7

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