Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Ser311Cys Polymorphisms of the Dopamine D2–Receptor Gene and Schizophrenia

Schizophrenia is a debilitating and complex mental disorder with a prevalence of approximately 1% worldwide. The etiology remains unclear, despite massive research efforts. Hyperactive dopaminergic signal transduction in the central nervous system is suggested to be involved in the pathophysiology o...

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Bibliographic Details
Main Authors: Masanari Itokawa, Tadao Arinami, Michio Toru
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319308734