EGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer

EGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer

Patients with EGFR mutations showed unfavorable response to programmed cell death-1 (PD-1) blockade immunotherapy in non-small cell lung cancer (NSCLC). Yet the underlying association between EGFR mutation and immune resistance remains largely unclear. We performed an integrated analysis of PD-ligan...

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Bibliographic Details
Main Authors: Zhong-Yi Dong, Jia-Tao Zhang, Si-Yang Liu, Jian Su, Chao Zhang, Zhi Xie, Qing Zhou, Hai-Yan Tu, Chong-Rui Xu, Li-Xu Yan, Yu-Fa Li, Wen-Zhao Zhong, Yi-Long Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:OncoImmunology
Subjects:
egfr
mutation burden
non-small cell lung cancer
programmed cell death protein-1
uninflamed
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1356145

Internet

http://dx.doi.org/10.1080/2162402X.2017.1356145

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