Integrated 16S rRNA Sequencing, Metagenomics, and Metabolomics to Characterize Gut Microbial Composition, Function, and Fecal Metabolic Phenotype in Non-obese Type 2 Diabetic Goto-Kakizaki Rats

Integrated 16S rRNA Sequencing, Metagenomics, and Metabolomics to Characterize Gut Microbial Composition, Function, and Fecal Metabolic Phenotype in Non-obese Type 2 Diabetic Goto-Kakizaki Rats

Type 2 diabetes mellitus (T2DM) is one of the most prevalent endocrine diseases in the world. Recent studies have shown that dysbiosis of the gut microbiota may be an important contributor to T2DM pathogenesis. However, the mechanisms underlying the roles of the gut microbiome and fecal metabolome i...

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Bibliographic Details
Main Authors: Weijun Peng, Jianhua Huang, Jingjing Yang, Zheyu Zhang, Rong Yu, Sharmeen Fayyaz, Shuihan Zhang, Yu-hui Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
T2DM
GK rats
gut microbiome
fecal metabolomics
Verrucomicrobia
Tenericutes
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03141/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.03141/full

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