PARP-14 binds specific DNA sequences to promote Th2 cell gene expression.

PARP-14 binds specific DNA sequences to promote Th2 cell gene expression.

PARP-14, a member of the poly ADP-ribose polymerase super family, promotes T helper cell 2 (Th2) differentiation by regulating interleukin-4 (IL-4) and STAT6-dependent transcription. Yet, whether PARP-14 globally impacts gene regulation has not been determined. In this report, using an RNA pol II Ch...

Full description

Bibliographic Details
Main Authors: Jonathan P Riley, Aishwarya Kulkarni, Purvi Mehrotra, Byunghee Koh, Narayanan B Perumal, Mark H Kaplan, Shreevrat Goenka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869773?pdf=render

Internet

http://europepmc.org/articles/PMC3869773?pdf=render

Similar Items