Recombinant Protein Containing B-Cell Epitopes of Different Loxosceles Spider Toxins Generates Neutralizing Antibodies in Immunized Rabbits

Recombinant Protein Containing B-Cell Epitopes of Different Loxosceles Spider Toxins Generates Neutralizing Antibodies in Immunized Rabbits

Loxoscelism is the most important form of araneism in South America. The treatment of these accidents uses heterologous antivenoms obtained from immunization of production animals with crude loxoscelic venom. Due to the scarcity of this immunogen, new alternatives for its substitution in antivenom p...

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Bibliographic Details
Main Authors: Sabrina de Almeida Lima, Clara Guerra-Duarte, Fernanda Costal-Oliveira, Thais Melo Mendes, Luís F. M. Figueiredo, Daysiane Oliveira, Ricardo A. Machado de Avila, Valéria Pereira Ferrer, Dilza Trevisan-Silva, Silvio S. Veiga, João C. Minozzo, Evanguedes Kalapothakis, Carlos Chávez-Olórtegui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
Loxosceles spider venom
sphingomyelinase D
astacin-like metalloprotease hyaluronidase
multiepitopic recombinant protein
B-cell epitope
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00653/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00653/full

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