BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer

BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer

Abstract Background We previously showed that BRCA-like profiles can be used to preselect individuals with the highest risk of carrying BRCA mutations but could also indicate which patients would benefit from double-strand break inducing chemotherapy. A simple, robust, and reliable assay for clinica...

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Bibliographic Details
Main Authors: Esther H. Lips, Anne Benard-Slagter, Mark Opdam, Caroline E. Scheerman, Jelle Wesseling, Frans B. L. Hogervorst, Sabine C. Linn, Suvi Savola, Petra M. Nederlof
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Breast Cancer Research
Subjects:
Breast cancer
BRCA1
BRCA2
Copy number analysis
digitalMLPA
Chemotherapy prediction
Online Access:http://link.springer.com/article/10.1186/s13058-020-01313-7

Internet

http://link.springer.com/article/10.1186/s13058-020-01313-7

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