Considering scores between unrelated proteins in the search database improves profile comparison

<p>Abstract</p> <p>Background</p> <p>Profile-based comparison of multiple sequence alignments is a powerful methodology for the detection remote protein sequence similarity, which is essential for the inference and analysis of protein structure, function, and evolution....

Full description

Bibliographic Details
Main Authors: Wang Yong, Sadreyev Ruslan I, Grishin Nick V
Format: Article
Language:English
Published: BMC 2009-12-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/10/399