Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells. Naïve tTreg from DA rats cultured with fully allogeneic PVG stimulator cells in the prese...

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Bibliographic Details
Main Authors: Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
transplant tolerance
T regulatoy cells
antigen specific Treg
CD8α
CD4+CD25+Foxp3+Treg
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02397/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02397/full

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