Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice

Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice

The main pathological hallmarks of Alzheimer's disease (AD) consist of amyloid plaques and neurofibrillary tangles. Hippocampal cell loss, atrophy and cholinergic dysfunction are also features of AD. The present work is aimed at studying the interactions between cholinergic denervation, APP pro...

Full description

Bibliographic Details
Main Authors: Francisco J. Gil-Bea, Gorka Gerenu, Barbara Aisa, Ludmil P. Kirazov, Reinhard Schliebs, Maria J. Ramírez
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
Cholinergic lesion
Basal forebrain
Hippocampus
Neurodegeneration
APP transgenic mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002355

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112002355

Similar Items