Na/H Exchange Regulatory Factor 1 Deficient Mice Show Evidence of Oxidative Stress and Altered Cisplatin Pharmacokinetics

Na/H Exchange Regulatory Factor 1 Deficient Mice Show Evidence of Oxidative Stress and Altered Cisplatin Pharmacokinetics

(1) Background: One third of patients who receive cisplatin develop an acute kidney injury. We previously demonstrated the Na/H Exchange Regulatory Factor 1 (NHERF1) loss resulted in increased kidney enzyme activity of the pentose phosphate pathway and was associated with more severe cisplatin nephr...

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Bibliographic Details
Main Authors: Adrienne M. Bushau-Sprinkle, Michelle T. Barati, Yuxuan Zheng, Walter H. Watson, Kenneth B. Gagnon, Syed Jalal Khundmiri, Kathleen T. Kitterman, Barbara J. Clark, Leah J. Siskind, Mark A. Doll, Michael E. Brier, Susan Coventry, Eleanor D. Lederer
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
cisplatin nephrotoxicity
redox status
acute kidney injury
Online Access:https://www.mdpi.com/2076-3921/10/7/1036

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https://www.mdpi.com/2076-3921/10/7/1036

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