Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in SPAST gene account for ∼40% of adult-onset patients. We have previously shown that SPAST patient cells have reduced organell...

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Bibliographic Details
Main Authors: Gautam Wali, Erandhi Liyanage, Nicholas F. Blair, Ratneswary Sutharsan, Jin-Sung Park, Alan Mackay-Sim, Carolyn M. Sue
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
hereditary spastic paraplegia
SPAST
axon transport
peroxisomes
axon degeneration
epothilone D
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00401/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00401/full

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