Pharmacophore-Based Virtual Screening of Novel Inhibitors and Docking Analysis for CYP51A from Penicillium italicum

Pharmacophore-Based Virtual Screening of Novel Inhibitors and Docking Analysis for CYP51A from Penicillium italicum

Sterol 14α-demethylases from Cytochrome P450 family (CYP51s) are essential enzymes in sterol biosynthesis and well-known as the target of antifungal drugs. The 3D structure of CYP51A from Penicillium italicum (PiCYP51A) was constructed through homology modeling based on the crystal structure of huma...

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Bibliographic Details
Main Authors: Yongze Yuan, Rui Han, Qianwen Cao, Jinhui Yu, Jiali Mao, Tingfu Zhang, Shengqiang Wang, Yuhui Niu, Deli Liu
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Marine Drugs
Subjects:
Penicillium italicum
PiCYP51A
pharmacophore
demethylase inhibitors
virtual screening
molecular docking
Online Access:http://www.mdpi.com/1660-3397/15/4/107

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http://www.mdpi.com/1660-3397/15/4/107

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