H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice

Abstract The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2 −/− knock-out (KO) mice to IAV infection but IAV of the H2 subtype have not been examined yet. Here, we demonstrate that TMPRSS2 is able to cleave H2-H...

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Bibliographic Details
Main Authors: Ruth Lydia Olga Lambertz, Ingo Gerhauser, Inga Nehlmeier, Sabine Gärtner, Michael Winkler, Sarah Rebecca Leist, Heike Kollmus, Stefan Pöhlmann, Klaus Schughart
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Virology Journal
Subjects:
Influenza a virus
H2 subtype
Host protease
TMPRSS2
Mouse mutant
Online Access:http://link.springer.com/article/10.1186/s12985-020-01323-z

Internet

http://link.springer.com/article/10.1186/s12985-020-01323-z

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