ROCK inhibitors modulate the physical properties and adipogenesis of 3D spheroids of human orbital fibroblasts in different manners

ROCK inhibitors modulate the physical properties and adipogenesis of 3D spheroids of human orbital fibroblasts in different manners

Abstract To elucidate the pharmacological effects of Rho‐associated coiled‐coil containing protein kinase inhibitors (ROCK‐is), ripasudil (Rip), Y27632, and KD025, on human orbital fatty tissue, the human orbital fibroblasts (HOFs) were three‐dimensional (3D) cultured for 12 days. The effects of ROC...

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Bibliographic Details
Main Authors: Fumihito Hikage, Hanae Ichioka, Megumi Watanabe, Araya Umetsu, Hiroshi Ohguro, Yosuke Ida
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:FASEB BioAdvances
Subjects:
human orbital fibroblasts (HOFs)
Rho kinase
ROCK
ROCK inhibitor
three‐dimensional (3D) tissue culture
Online Access:https://doi.org/10.1096/fba.2021-00037

Internet

https://doi.org/10.1096/fba.2021-00037

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