Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors

Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors

Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in vitro antiproliferative activity of a family of b...

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Bibliographic Details
Main Authors: Aurora Molinari, Alfonso Oliva, Marlene Arismendi-Macuer, Leda Guzmán, Waldo Acevedo, Daniel Aguayo, Raúl Vinet, Arturo San Feliciano
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
1<i>H</i>-benzo[<i>f</i>]indazole-4,9-diones
benzoindazolequinones
antiproliferative activity
COX-2 inhibitors
docking
Online Access:https://www.mdpi.com/1420-3049/24/12/2261

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https://www.mdpi.com/1420-3049/24/12/2261

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