Development and Characterization of High Efficacy Cell-Penetrating Peptide via Modulation of the Histidine and Arginine Ratio for Gene Therapy

Development and Characterization of High Efficacy Cell-Penetrating Peptide via Modulation of the Histidine and Arginine Ratio for Gene Therapy

Cell-penetrating peptides (CPPs), as non-viral gene delivery vectors, are considered with lower immunogenic response, and safer and higher gene capacity than viral systems. In our previous study, a CPP peptide called RALA (arginine rich) presented desirable transfection efficacy and owns a potential...

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Bibliographic Details
Main Authors: Yu Liu, Huan-Huan Wan, Duo-Mei Tian, Xiao-Jun Xu, Chang-Long Bi, Xiao-Yong Zhan, Bi-Hui Huang, Yun-Sheng Xu, Le-Ping Yan
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Materials
Subjects:
gene therapy
cell penetrating peptide
histidine
RALA peptide
endosomal escaping
Online Access:https://www.mdpi.com/1996-1944/14/16/4674

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https://www.mdpi.com/1996-1944/14/16/4674

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