Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration

Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration

<p>Abstract</p> <p>Background</p> <p>Leber's hereditary optic neuropathy (LHON) is caused by mutations in the complex I subunits of the respiratory chain. Although patients have been treated with idebenone since 1992, the efficacy of the drug is still a matter of d...

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Bibliographic Details
Main Authors: Angebault Claire, Gueguen Naïg, Desquiret-Dumas Valérie, Chevrollier Arnaud, Guillet Virginie, Verny Christophe, Cassereau Julien, Ferre Marc, Milea Dan, Amati-Bonneau Patrizia, Bonneau Dominique, Procaccio Vincent, Reynier Pascal, Loiseau Dominique
Format: Article
Language:English
Published: BMC 2011-12-01
Series:BMC Research Notes
Online Access:http://www.biomedcentral.com/1756-0500/4/557

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http://www.biomedcentral.com/1756-0500/4/557

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