Effects of NLRP3 inflammasome blockade on postresuscitation cerebral function in a rat model of cardiopulmonary resuscitation

Effects of NLRP3 inflammasome blockade on postresuscitation cerebral function in a rat model of cardiopulmonary resuscitation

Cardiac arrest (CA) remains a major public health issue. Inflammatory responses with overproduction of interleukin-1β regulated by NLRP3 inflammasome activation play a crucial role in cerebral ischemia/reperfusion injury. We investigated the effects of the selective NLRP3-inflammasome inhibitor MCC9...

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Bibliographic Details
Main Authors: Guanghui Zheng, Jing Xu, Fenglian He, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L. Bradley, Mary Ann Peberdy, Joseph P. Ornato, Stefano Toldo, Tong Wang, Wanchun Tang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cardiac arrest
Cerebral function
Microcirculation
NLRP3 inflammasome
MCC950
Postresuscitation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008763

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http://www.sciencedirect.com/science/article/pii/S0753332221008763

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