Mechanistic analyses in kidney transplant recipients prospectively randomized to two steroid free regimen-Low dose Tacrolimus with Everolimus versus standard dose Tacrolimus with Mycophenolate Mofetil.

Mechanistic analyses in kidney transplant recipients prospectively randomized to two steroid free regimen-Low dose Tacrolimus with Everolimus versus standard dose Tacrolimus with Mycophenolate Mofetil.

Calcineurin inhibitors (CNI), the cornerstone of immunosuppression after transplantation are implicated in nephrotoxicity and allograft dysfunction. We hypothesized that combined low doses of CNI and Everolimus (EVR) may result in better graft outcomes and greater tolerogenic milieu. Forty adult ren...

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Bibliographic Details
Main Authors: Opas Traitanon, James M Mathew, Aneesha Shetty, Sai Vineela Bontha, Daniel G Maluf, Yvonne El Kassis, Sook H Park, Jing Han, M Javeed Ansari, Joseph R Leventhal, Valeria Mas, Lorenzo Gallon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0216300

Internet

https://doi.org/10.1371/journal.pone.0216300

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