Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and inhibits the...

Full description

Bibliographic Details
Main Authors: Yaser Atlasi, Rubina Noori, Claudia Gaspar, Patrick Franken, Andrea Sacchetti, Haleh Rafati, Tokameh Mahmoudi, Charles Decraene, George A Calin, Bradley J Merrill, Riccardo Fodde
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3642041?pdf=render

Internet

http://europepmc.org/articles/PMC3642041?pdf=render

Similar Items