A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

Creatine serves as fast energy buffer in organs of high-energy demand such as brain and skeletal muscle. L-Arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase are responsible for endogenous creatine synthesis. Subsequent uptake into target organs like skeletal muscle,...

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Bibliographic Details
Main Authors: Malte Stockebrand, Ali Sasani, Devashish Das, Sönke Hornig, Irm Hermans-Borgmeyer, Hannah A. Lake, Dirk Isbrandt, Craig A. Lygate, Arend Heerschap, Axel Neu, Chi-Un Choe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
creatine transporter
skeletal muscle
energy metabolism
in vivo magnetic spectroscopy
L-arginine:glycine amidinotransferase (AGAT)
guanidinoacetate N-methyltransferase (GAMT)
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00773/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00773/full

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