Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements

Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements

Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion prior to use as cell-based therapies in immunological and tissue repair applications. Aging and expansion of BM-MSCs induce epigenetic changes that can impact therapeutic outcomes. By applying sequencing-based metho...

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Bibliographic Details
Main Authors: Kalyan K. Pasumarthy, Naresh Doni Jayavelu, Lotta Kilpinen, Colin Andrus, Stephanie L. Battle, Matti Korhonen, Petri Lehenkari, Riikka Lund, Saara Laitinen, R. David Hawkins
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
epigenetics
DNA methylation
enhancer elements
stem cell biology
bone marrow MSCs
aging
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303284

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http://www.sciencedirect.com/science/article/pii/S2213671117303284

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