A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice

A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice

Middle East respiratory syndrome coronavirus (MERS-CoV), a new coronavirus that has been causing severe and fatal acute respiratory illnesses in humans since its outbreak in 2012, has raised public fear worldwide. The development of prophylactics and therapeutics is urgently needed to prevent and co...

Full description

Bibliographic Details
Main Authors: Entao Li, Hang Chi, Pei Huang, Feihu Yan, Ying Zhang, Chuanyu Liu, Zhenshan Wang, Guohua Li, Shengnan Zhang, Ruo Mo, Hongli Jin, Hualei Wang, Na Feng, Jianzhong Wang, Yuhai Bi, Tiecheng Wang, Weiyang Sun, Yuwei Gao, Yongkun Zhao, Songtao Yang, Xianzhu Xia
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Viruses
Subjects:
MERS-CoV
subunit vaccine
bacterium-like particles
intranasal administration
mucosal immune
Online Access:https://www.mdpi.com/1999-4915/11/9/799

Internet

https://www.mdpi.com/1999-4915/11/9/799

Similar Items