Proteomic Analysis of Breast Cancer Resistance to the Anticancer Drug RH1 Reveals the Importance of Cancer Stem Cells

Proteomic Analysis of Breast Cancer Resistance to the Anticancer Drug RH1 Reveals the Importance of Cancer Stem Cells

Antitumor drug resistance remains a major challenge in cancer chemotherapy. Here we investigated the mechanism of acquired resistance to a novel anticancer agent RH1 designed to be activated in cancer cells by the NQO1 enzyme. Data show that in some cancer cells RH1 may act in an NQO1-independent wa...

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Bibliographic Details
Main Authors: Dalius Kuciauskas, Nadezda Dreize, Marija Ger, Algirdas Kaupinis, Kristijonas Zemaitis, Vaidotas Stankevicius, Kestutis Suziedelis, Jonas Cicenas, Lee M. Graves, Mindaugas Valius
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
RH1
chemotherapy
cancer drug resistance
JNK
c-KIT
protein kinases
label-free proteomics
MIBs
phosphoproteome
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/11/7/972

Internet

https://www.mdpi.com/2072-6694/11/7/972

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