PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion

RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this, we performed a genetic screen in Drosophila, aiming to find mutations that cooperate with oncogenic R...

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Bibliographic Details
Main Authors: Xianjue Ma, Jin-Yu Lu, Yongli Dong, Daming Li, Juan N. Malagon, Tian Xu
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
Ras
Fmt
PpV
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307842